About

Project Background

The HLA Serotype Database is a comprehensive resource for HLA serological analysis. Our mission is to provide researchers and clinicians with accurate, up-to-date information about HLA serotypes and their relationships.

Data Provenance

What version of the HATS source data this site is currently serving, which IPD-IMGT/HLA files its WHO assignments came from, and when it was last imported from upstream.

How the Data Is Kept Current

A scheduled job runs every night and compares the latest commit of the upstream HATS repository with the one this site was built from. If nothing changed, it stops. If a new release is present, the job:

  1. Reads the HATS release version and the IPD-IMGT/HLA version the release was generated from directly from the HATS files.
  2. Downloads the matching IPD-IMGT/HLA release files (the WMDA serology files rel_dna_ser.txt, hla_nom.txt and rel_ser_ser.txt, and the allele list with accessions), verifies them against IPD's checksums, and derives every allele's WHO assignment status and accession; the IPD-IMGT/HLA Comparison tab under View Data is computed at this step. The import fails rather than proceed without these files.
  3. Imports the new release alongside the current one, so the site keeps serving the current data while rows load, then validates the new release against it (row counts, serotype counts and per-locus ranges).
  4. Promotes the new release in a single step, rebuilds the bulk download files and their manifest, and keeps only the two most recent releases.
  5. Opens a GitHub issue for the maintainers if any step fails, in which case the site continues to serve the previous release.

The Data Provenance box above records the outcome: the HATS version and commit, the IPD-IMGT/HLA files used, and the time of the last import. The getLatestVersion API query returns the same information so pipelines can detect updates.

Contact Us

If you have questions or find any issues with the database or API, please contact us

Our Team

William Lane

William Lane

MD, PhD, A(ACHI)

Website Programmer

Associate Professor of Pathology, Harvard Medical School; Director, Tissue Typing Laboratory, Brigham and Women's Hospital, Boston, MA

He is an Associate Professor of Pathology at Harvard Medical School and the Lab Director of the Tissue Typing Laboratory at Brigham and Women's Hospital (BWH) in Boston, MA. He is board-certified in Clinical Pathology, Blood Banking/Transfusion Medicine, and Clinical Informatics, and he is also an ACHI-certified HLA Lab Director. He is co-founder of the Transfusion Medicine Question of the Day. His research interests include red blood cell (RBC) and platelet (PLT) antigen genotyping. In particular, he has developed databases and websites for RBC and PLT antigen phenotype and genotype correlations, along with automated interpretive algorithms for next-generation sequencing and high-density DNA array data. He is also a strong proponent of ABO genotyping in transplantation.

Kazutoyo Osoegawa

Kazutoyo Osoegawa

PhD

HATS (HLA Allele To Serotype) Programmer

Research Science & Technical Lead, Stanford Blood Center, Palo Alto, California

Kazutoyo Osoegawa is a Research Science & Technical Lead at the Stanford Blood Center (SBC) where he has worked for 11 years. He leads various innovation projects focused on HLA in both molecular and serology, and development of tools to improve work efficacy for the clinical laboratory.

Cathi Murphey

Cathi Murphey

PhD, HCLD/CC(ABB), A(ACHI)

Director, Histocompatibility & Immunogenetics Laboratory, Southwest Immunodiagnostics, Inc., San Antonio, TX

She is the histocompatibility and immunogenetics laboratory director of Southwest Immunodiagnostics, Inc. in San Antonio. She has more than 30+ years of experience in the field of Histocompatibility and Immunogenetics. Dr. Murphey has served as the chair of the UNOS Histocompatibility Committee, member of the UNOS Continuous Distribution Kidney/Pancreas Workgroup and the UNOS Kidney committee. She has published numerous papers and book chapters. She is also active in ASHI, has served on many committees including the National Clinical Affairs Committee (NCAC) and the President of ASHI. Dr. Murphey is also a member of American Transplantation Society (AST) and International Society of Heart and Lung Transplantation (ISHLT).

Marcelo A. Fernandez-Vina

Marcelo A. Fernandez-Vina

PhD, F(ACHI)

HATS (HLA Allele To Serotype) Project Leader

Professor, Department of Pathology, Stanford University School of Medicine, Stanford, CA

Marcelo Fernández-Viña, PhD, F(ACHI) is a Professor for the Department of Pathology at Stanford University Medical School and serves as Director of the Histocompatibility, Immunogenetics and Disease Profiling Laboratory at this institution. He has been working in the fields of Histocompatibility and Immunogenetics since 1982. He has more than 250 peer reviewed publications, many of them focusing on HLA variation in multiple world populations, identifying susceptibility and resistance factors for diseases. In addition his work also focus in the definition of HLA serologic and molecular mismatches in the evaluation of their impact in the outcome of allogeneic transplants. He served as expert Consultant for Donor Searches for NMDP and as President Elect, President and Past President of the American Society for Histocompatibility and Immunogenetics. He served as a member of the Board of Directors and the Executive Committee for the United Network for Organ Sharing. He served as Co-Chair of the Immunobiology Committee of the CIBMTR. He also served as a member of the HHS Advisory Council on Blood Stem Cell Transplantation (ACBSCT). He serves as HLA Expert Consultant for the NMDP for the HRSA contract and is a member of the Histocompatibility Advisory Group for NMDP. He is Councilor of the International Histocompatibility Workshop and a member of the WHO Nomenclature Committee for Factors of the HLA System and was Chairman of the (17th) International HLA & Immunogenetics Workshop, and Past President of the International HLA & Immunogenetics Workshop.